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Personal essay

My father was born poor in the countryside. 

He moved to the city to run away from the memory of hunger that had plagued him since he was young. Although he was never able to attain a higher education degree he was determined that the lives of his family would be different and they would never experience hunger as he had. 

In spite of all his efforts, tragedy struck again. This time, it was related to my birth. My Father stayed up all night to take care of his wife who was suffering from gestational diabetes which almost led to the loss of her eyesight and paralysis of her hands. Without a wink of sleep, he left at 4am again to earn 80 dollars for a full day of manual labor to ensure he had food for his wife, my older brother and I to eat. To this day, my mother tells me, he was never frustrated. 

When I grew older, l remember my parents conversing each night when we laid down to sleep. It wasn’t a pretty conversation but dosed with stories of manual workers who lived from hand to mouth, my Father being one of them. These workers struggled constantly with worries about whether they would get paid the next day or whether an injury would prevent them from putting food on the tables of their family.

Eventually, the day came, the day I saw my father shed tears for the first time. His friend lost an eye due to cataracts because he wasn’t able to afford the 200 dollars required for a 10 minute operation. With that lost eye, the friend laughed it off and went to work thinking it was fate, after all he still had to put food on the table.

Poverty makes the most simple diseases seem incurable. It makes the poor believe that it’s fate and they must accept the consequences. But, I don’t believe in that fate and I believe all people deserve better than that. My Father tearfully implored me to become a person who helps those in need, but he didn’t need to convince me. After witnessing this incident I swore to myself that although I may not be able to eradicate their poverty completely, I would provide hope for those that are less fortunate. 

At first, I wasn’t sure what direction I would take to provide this hope and help, but as I grew older, I realised I had an affinity for sciences, especially biology. Towards the end of High School, I became fascinated by the life changing impact artificial organs can have for those that cannot afford ordinary donor organs and consequently that became my life's goal. 

While chasing this dream, the responsibility I have as a person who has had a front row seat in watching the lives of poor people is very evident to me. This has led me to participate in every research project, even a collaboration with university student’s while I was in high school, so that I could gain relevant experience as a researcher. I worked doubly hard to gain and keep scholarships because I knew the money my mother gave me for my admission fee was an opportunity cost for her diabetes treatment. Staying in the library until 2 am did not faze me as I knew it was nothing in comparison to my parent’s sacrifices. And the sacrifices of other parents that bore a similar experience to them.  

 

My Father’s initial promise when he left the countryside still stands, I’ve never been hungry and luckily I’ve never been sick like my mother. But I can see how the tragedy of achieving that promise still marks their lives and those around them. I see my dad’s friend still working hard for his family with one eye lost. This is why my purpose is to bring hope back, even if it’s in one aspect of their lives. I choose all of them.  

Research Plan 

Although an organ transplant is a well-established operation in 2020, social problems -such as black-market sales and difficult access to organs by the poor- still get in the way and limit the power of the medical system. The limited supplies from donors, transplant rejection, and low efficiency of transplanted organs are the main reasons not enough people can get their life saved, and I have been interested in studying this field in order to grant better access to organs.

 

Firstly, I would like to study the communication between immune cells and mechanism of them in order to avoid transplant rejection. According to the Quorum Sensing study, when there is a microbial intrusion, the infection symptoms do not appear immediately. And if Quorum sensing is controlled properly, it becomes possible to suppress the infection without additional treatment. Similarly, I have thought about studying the immune system in order to avoid the prescription of immunosuppressants which can provoke undesirable side effects, as well as create a variety of cross-species transplants in order to increase the number of available organs.

 

Secondly, I am interested in gene knockouts using CRISPR, a technique of molecular biology that has entered the spotlight recently. Both antibody rejection and cellular rejection, which are major problems when it comes to transplantation, are related to gene activation in targeted organs. In previous studies, the pig cornea and the islet of Langerhans had little antigen against Gal (Galactose-alpha-1,3-galactose), which can cause acute transplant rejection, and showed possibility of cross-species transplantation. Neutralization of antigen corded gene and development of elaborate CRISPR techniques will be an effective way of controlling antigen related genes as well as rejection reactions early on when doing transplants.

 

Thirdly, I want to research about individual specialized organ development and damaged organ regeneration using stem cells. In addition to the rejection response issues resulting from organ transplants, the issue of longevity and efficiency of transplanted organs is important. Because current transplantation uses non-self oriented organs, there would be certain limited efficiency rate. I believe it to be ultimately achieved through individual customized organ production.

 

Despite the fact that I did not have the chance to work in a laboratory for a long time in my field of interest, I have continuously participated in research projects since my high school days and tried to gain the ability to quickly understand any kind of research process through various studies such as a CCD in honeybee study, a cell communication study, and a microorganism study.

CV (Resume) 

CV, Lee Jae Ho

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©2020 by Lee Jae Ho

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